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The association of polymorphisms in 5-fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer

✍ Scribed by Afzal, Shoaib; Gusella, Milena; Jensen, Søren Astrup; Vainer, Ben; Vogel, Ulla; Andersen, Jon Trærup; Brødbæk, Kasper; Petersen, Morten; Jimenez-Solem, Espen; Adleff, Vilmos


Book ID
111943660
Publisher
Future Medicine
Year
2011
Tongue
English
Weight
615 KB
Volume
12
Category
Article
ISSN
1462-2416

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## Abstract Orotate phosphoribosyl transferase (OPRT) is the main enzyme that involves in phosphoribosylation of 5‐fluorouracil (5‐FU), an essential step that leads to tumor growth inhibition. In our study, the prognostic relevance of OPRT, thymidylate synthase (TS) and dihydropyrimidine dehydrogen