𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Lack of Benefit of 5-Fluorouracil-Based Adjuvant Chemotherapy in Colorectal Cancer with Microsatellite Instability

✍ Scribed by Lori Johnson; Edward Chu


Book ID
119616946
Publisher
CIG Media Group, LP.
Year
2002
Tongue
English
Weight
102 KB
Volume
2
Category
Article
ISSN
1533-0028

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## Abstract Orotate phosphoribosyl transferase (OPRT) is the main enzyme that involves in phosphoribosylation of 5‐fluorouracil (5‐FU), an essential step that leads to tumor growth inhibition. In our study, the prognostic relevance of OPRT, thymidylate synthase (TS) and dihydropyrimidine dehydrogen