Prognostic impact of orotate phosphoribosyl transferase activity in resectable colorectal cancers treated by 5-fluorouracil-based adjuvant chemotherapy

Prognostic impact of orotate phosphoribo

Prognostic impact of orotate phosphoribosyl transferase among 5-fluorouracil metabolic enzymes in resectable colorectal cancers treated by oral 5-fluorouracil-based adjuvant chemotherapy

✍ Takumi Ochiai; Kazuhiko Nishimura; Hajime Noguchi; Masayuki Kitajima; Akira Tsuk 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 160 KB

## Abstract Orotate phosphoribosyl transferase (OPRT) is the main enzyme that involves in phosphoribosylation of 5‐fluorouracil (5‐FU), an essential step that leads to tumor growth inhibition. In our study, the prognostic relevance of OPRT, thymidylate synthase (TS) and dihydropyrimidine dehydrogen