Objective. We examined the risk for depressive symptoms associated with age, education, ethnicity, gender, marital status, apolipoprotein E genotype (APOE) and memory complaints among non-demented elderly (560 years). Design. Cross-sectional study of geriatric patients recruited from a free memory
The association between depressive symptoms and cognitive decline in community-dwelling elderly persons
β Scribed by Hannie C. Comijs; Cees Jonker; Aartjan T. F. Beekman; Dorly J. H. Deeg
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 72 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0885-6230
- DOI
- 10.1002/gps.343
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
Objective
To investigate whether depressive symptoms predict specific types of cognitive decline in order to elucidate the association between late life depression and cognitive decline.
Background
Mechanisms underlying the association between late life depression and cognitive decline are still unclear.
Method
Six hundred and fortyβone elderly persons of the Longitudinal Aging Study Amsterdam (LASA) aged 70β85 were examined by means of two measurement occasions over a period of 3 years. Depressive symptoms were assessed by means of the CESβD. Various cognitive functions were examined using neuropsychological tests.
Results
Depressive symptoms were associated with decline in speed of information processing over a 3βyear period, whereas there was no association between depression and increasing memory impairment or global mental deterioration.
Conclusion
These findings suggest that depressive symptoms are associated with subcortical pathology, most probable white matter lesions. Copyright Β© 2001 John Wiley & Sons, Ltd.
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