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The association between depressive symptoms and cognitive decline in community-dwelling elderly persons

✍ Scribed by Hannie C. Comijs; Cees Jonker; Aartjan T. F. Beekman; Dorly J. H. Deeg


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
72 KB
Volume
16
Category
Article
ISSN
0885-6230

No coin nor oath required. For personal study only.

✦ Synopsis


Abstract

Objective

To investigate whether depressive symptoms predict specific types of cognitive decline in order to elucidate the association between late life depression and cognitive decline.

Background

Mechanisms underlying the association between late life depression and cognitive decline are still unclear.

Method

Six hundred and forty‐one elderly persons of the Longitudinal Aging Study Amsterdam (LASA) aged 70–85 were examined by means of two measurement occasions over a period of 3 years. Depressive symptoms were assessed by means of the CES‐D. Various cognitive functions were examined using neuropsychological tests.

Results

Depressive symptoms were associated with decline in speed of information processing over a 3‐year period, whereas there was no association between depression and increasing memory impairment or global mental deterioration.

Conclusion

These findings suggest that depressive symptoms are associated with subcortical pathology, most probable white matter lesions. Copyright Β© 2001 John Wiley & Sons, Ltd.


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