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Associations between holotranscobalamin, vitamin B12, homocysteine and depressive symptoms in community-dwelling elders

✍ Scribed by DJ Robinson; C O'Luanaigh; E Tehee; H O'Connell; F Hamilton; AV Chin; R Coen; AM Molloy; J Scott; CJ Cunningham; BA Lawlor

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 123 KB
Volume: 26
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.2530

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

Vitamin B12 and homocysteine have been shown to be associated with depression or depressive symptoms, but the relationship has not been universal. Both vitamin B12 and homocysteine may exert an effect via vascular mechanisms; it is possible that other mechanisms apply. Holotranscobalamin is a novel, more accurate measure of tissue vitamin B12.

Objectives

To examine associations between vitamin B12, serum folate, holotranscobalamin, homocysteine and depressive symptoms in a sample of healthy elderly.

Methods

Cross‐sectional, observational community based study.

Results

Lower levels of holotranscobalamin and vitamin B12 were associated with higher levels of depressive symptoms when controlled for Mini‐mental state examination scores and psychosocial and cardiovascular risk factors. Homocysteine was not associated with depressive symptoms when biological and psychosocial covariates were included.

Conclusions

It is possible that low levels of vitamin B12 or holotranscobalamin are associated with depressive symptoms via mechanisms other than vascular pathology.

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