Factors associated with depressive symptoms in non-demented community-dwelling elderly

✍ Scribed by Dylan G. Harwood; Warren W. Barker; Raymond L. Ownby; Michael Mullan; Ranjan Duara

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 220 KB
• Volume: 14
• Category: Article
• ISSN: 0885-6230
• DOI: 10.1002/(sici)1099-1166(199905)14:5<331::aid-gps911>3.0.co;2-8

✦ Synopsis

Objective. We examined the risk for depressive symptoms associated with age, education, ethnicity, gender, marital status, apolipoprotein E genotype (APOE) and memory complaints among non-demented elderly (560 years).

Design. Cross-sectional study of geriatric patients recruited from a free memory screening oered to the community.

Sample. This investigation included 506 community-residing elderly subjects who were screened for cognitive impairment and classi®ed as non-demented based on age and education-adjusted Folstein Mini-Mental State Exam (MMSAdj) scores of 24 or greater.

Results. The prevalence of signi®cant depressive symptoms (Hamilton Depression Rating Scale 512 was 12.1% (N 61). Increased risk for depression was associated with female gender (OR 2X3; 95% CI 1X1±4X8; p 5 0X05), Cuban American ethnicity (OR 4X9; 95% CI 2X3±10X4; p 5 0X0001) and memory complaints (OR 1X3; 95% CI 1X2±1X4; p 5 0X0001). The APOE allele frequencies in the current sample were 0.07, 0.80 and 0.13 for the e2, e3 and e4 alleles, respectively.

Conclusions. The results suggest that signs and symptoms of depression are common among non-demented elderly subjects in the community. In this study, mood disturbances were associated with Cuban American ethnicity, female gender and more memory complaints. Factors that were not con®rmed by this study include age, education, marital status and APOE genotype. The observed APOE e4 allele frequency of 0.13 supports the normal cognitive classi®cation of the sample.