✍ Scribed by H.G. Burns; H.I. Glass
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Quaternary ammonium compounds formed at the site of action by spontaneous cyclization of tertiary ω‐haloalkylamine precursors may have interesting pharmacological properties. In order to study the pharmacokinetics of the cyclization principle, a series of new tertiary ω‐haloalkylamines
## Abstract The possibilities of tritium labelling of tofizopam (**1**) at high specific activity were investigated. Two methods, one by isotopic exchange, and one by catalysed halogen‐tritium replacement were developed. The latter was found to be more rational, and **1** specifically labelled with
## Abstract Tritium labelled amitriptyline (__1__) of high specific activity was prepared. The tritium was incorporated by catalysed isotope exchange into the precursor dibenzosuberone, which had been previously converted into a cyclic ketal, in order to protect the oxo‐group against reduction. It