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The aryl hydrocarbon receptor ligands 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene regulate distinct genetic networks

✍ Scribed by Swedenborg, Elin; Kotka, Maria; Seifert, Martin; Kanno, Jun; Pongratz, Ingemar; Rüegg, Joëlle

Book ID: 119323380
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 297 KB
Volume: 362
Category: Article
ISSN: 0303-7207
DOI: 10.1016/j.mce.2012.05.006

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## Abstract Epidemiological and laboratory studies suggested that exposure to 2,3,7,8‐tetrachlorodibenzo‐__p__‐dioxin (TCDD) affects glucose homeostasis and increases the incidence of type 2 diabetes mellitus. To evaluate the effects of TCDD on insulin secretion from islets of Langerhans (islets),