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Identification of aryl hydrocarbon receptor binding targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin

✍ Scribed by Raymond Lo; Trine Celius; Agnes L. Forgacs; Edward Dere; Laura MacPherson; Patricia Harper; Timothy Zacharewski; Jason Matthews


Book ID
113924925
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
917 KB
Volume
257
Category
Article
ISSN
0041-008X

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## Abstract Epidemiological and laboratory studies suggested that exposure to 2,3,7,8‐tetrachlorodibenzo‐__p__‐dioxin (TCDD) affects glucose homeostasis and increases the incidence of type 2 diabetes mellitus. To evaluate the effects of TCDD on insulin secretion from islets of Langerhans (islets),