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The application of achiral/chiral coupled-column high-performance liquid chromatography to biomedical analysis

✍ Scribed by Irving W. Wainer

Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 390 KB
Volume: 7
Category: Article
ISSN: 0731-7085
DOI: 10.1016/0731-7085(89)80042-1

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✦ Synopsis

The use of achiral/chiral coupled-column HPLC in the direct analysis of the enantiomers of chiral drugs in biological samples is reviewed. The method has been applied to a study of the pharmacokinetics of (+)- and (-)-terbutaline, the resolution of the stereoisomers of leucovorin and the determination of warfarin enantiomers in serum.

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