CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta
โฆ LIBER โฆ
The Appearance of the CD4CD8 Phenotype on Activated T Cells:: Possible Role of Antigen Transfer
โ Scribed by Ruth Rabinowitz; Rivka Hadar; Michael Schlesinger
- Book ID
- 117415632
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 414 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0198-8859
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We evaluated phenotype and apoptotic status of normal CD4 ุ CD69 ุ and CD8 ุ CD69 ุ peripheral blood T-lymphocytes after short-term challenge with escalating concentrations of phytohemagglutinin (PHA). The frequency of CD69-coexpressing CD4 ุ and CD8 ุ T-cells and CD69 staining intensity increased f