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The apoptosis of bovine lens epithelial cells induced by proteasome inhibitor MG132

✍ Scribed by Xing Xing; Yizhen Hu; Yang Cao; Zhirong Xu


Book ID
107405811
Publisher
Springer-Verlag
Year
2008
Tongue
Chinese
Weight
444 KB
Volume
28
Category
Article
ISSN
0510-9752

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## Abstract In cervical carcinogenesis, the p53 tumor suppressor pathway is disrupted by HPV (human papilloma virus) E6 oncogene expression. E6 targets p53 for rapid proteasome‐mediated degradation. We therefore investigated whether proteasome inhibition by MG132 could restore wild‐type p53 levels