## Abstract In cervical carcinogenesis, the p53 tumor suppressor pathway is disrupted by HPV (human papilloma virus) E6 oncogene expression. E6 targets p53 for rapid proteasomeβmediated degradation. We therefore investigated whether proteasome inhibition by MG132 could restore wildβtype p53 levels
β¦ LIBER β¦
Gap junctions sensitize cancer cells to proteasome inhibitor MG132-induced apoptosis
β Scribed by Tao Huang; Ying Zhu; Xin Fang; Yuan Chi; Masanori Kitamura; Jian Yao
- Book ID
- 108586594
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 752 KB
- Volume
- 101
- Category
- Article
- ISSN
- 1347-9032
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## Abstract Proteasome inhibitors are known to induce apoptosis in a variety of cancer cells. On the other hand, maspin, a nonβinhibitory serine protease inhibitor, is shown to sensitize cancer cells to therapeutic agents that induce apoptosis. We examined the consequence of maspin expression in pr