𝔖 Bobbio Scriptorium
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MG132, a proteasome inhibitor, induces apoptosis in tumor cells

✍ Scribed by Na GUO; Zhilan PENG

Book ID
114829953
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
430 KB
Volume
9
Category
Article
ISSN
1743-7555

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## Abstract In cervical carcinogenesis, the p53 tumor suppressor pathway is disrupted by HPV (human papilloma virus) E6 oncogene expression. E6 targets p53 for rapid proteasome‐mediated degradation. We therefore investigated whether proteasome inhibition by MG132 could restore wild‐type p53 levels