✦ LIBER ✦

The antioxidative effect of ganhuangenin against lipid peroxidation

✍ Scribed by Beong Ou Lim; Byung Pal Yu; Suck Chang Kim; Dong Ki Park

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 68 KB
Volume: 13
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199909)13:6<479::aid-ptr484>3.0.co;2-m

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✦ Synopsis

The antioxidative effect of ganhuangenin (GHG), isolated from Scutellaria baicalensis Georgi, was examined by measuring its ability to suppress the formation of phospatidylcholine hydroperoxide (PCOOH). The results show that a pretreatment with GHG effectively suppressed PCOOH formation, which was initiated by the peroxyl-generating oxidant, AAPH (2,2'-azobis-2-aminopropane hydrochloride). The protective action of GHG against the formation of the PCOOH was observed in liver, lung, and kidney. When compared with other known antioxidants, we found the antioxidative potency of GHG to be greater than that of a-tocopherol. Our data strongly indicate that GHG is a powerful antioxidant against lipid peroxidation and is, therefore, responsible for this prophylactic effect.

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