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The Allosteric Mechanism of Yeast Chorismate Mutase: A Dynamic Analysis

✍ Scribed by Yifei Kong; Jianpeng Ma; Martin Karplus; William N. Lipscomb

Book ID
116662600
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
758 KB
Volume
356
Category
Article
ISSN
0022-2836

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On the mechanism of chorismate mutases:
On the mechanism of chorismate mutases: Clues from wild-type E. coli enzyme and a site-directed mutant related to yeast chorismate mutase
✍ Christophe C Galopin; Sheng Zhang; David B Wilson; Bruce Ganem πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 French βš– 207 KB

Thermodynamic parameters for E. coli chorismate mutase are reported. In addition, site-directed mutagenesis studies provide a direct mechanistic link to yeast chorismate mutase, further indicating the importance of entropic restriction and hydrogen bonding in the enzymic catalysis of Claisen rearran