On the mechanism of chorismate mutases: Clues from wild-type E. coli enzyme and a site-directed mutant related to yeast chorismate mutase

✍ Scribed by Christophe C Galopin; Sheng Zhang; David B Wilson; Bruce Ganem

• Publisher: Elsevier Science
• Year: 1996
• Tongue: French
• Weight: 207 KB
• Volume: 37
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(96)02007-2

✦ Synopsis

Thermodynamic parameters for E. coli chorismate mutase are reported. In addition, site-directed mutagenesis studies provide a direct mechanistic link to yeast chorismate mutase, further indicating the importance of entropic restriction and hydrogen bonding in the enzymic catalysis of Claisen rearrangements.