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The adenomatous polyposis coli (APC) tumour suppressor – genetics, function and disease

✍ Scribed by M. Sieber, Oliver; P. Tomlinson, Ian; Lamlum, Hanan

Book ID
114381939
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
600 KB
Volume
6
Category
Article
ISSN
1357-4310

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✍ Hiroki Nagase; Yusuke Nakamura 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 823 KB

Several investigators have reported germline mutations of the APC gene in patients with familial adenomatous polyposis (FAP) as well as somatic mutations in tumors developed in digestive organs (stomach, pancreas, colon, and rectum). Those results provide evidence that inactivation of the APC gene p