Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor
✍ Scribed by J.H. van Es; C. Kirkpatrick; M. van de Wetering; M. Molenaar; A. Miles; J. Kuipers; O. Destrée; M. Peifer; H. Clevers
- Book ID
- 114321375
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 328 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0960-9822
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Several investigators have reported germline mutations of the APC gene in patients with familial adenomatous polyposis (FAP) as well as somatic mutations in tumors developed in digestive organs (stomach, pancreas, colon, and rectum). Those results provide evidence that inactivation of the APC gene p
## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm