Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours
โ Scribed by Giarola, M; Wells, D; Mondini, P; Pilotti, S; Sala, P; Azzarelli, A; Bertario, L; Pierotti, MA; Delhanty, JDA; Radice, P
- Book ID
- 109838600
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 1015 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0007-0920
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Several investigators have reported germline mutations of the APC gene in patients with familial adenomatous polyposis (FAP) as well as somatic mutations in tumors developed in digestive organs (stomach, pancreas, colon, and rectum). Those results provide evidence that inactivation of the APC gene p
Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T
Patients with Familial Adenomatous Polyposis (FAP) manifest numerous colorectal adenomas as well as benign and malignant extra-colonic lesions. Adenomatous polyposis coli (APC) gene mutations are the underlying genetic defect in FAP. We analyzed germline D N A of 81 unrelated FAP patients and evalua