Several investigators have reported germline mutations of the APC gene in patients with familial adenomatous polyposis (FAP) as well as somatic mutations in tumors developed in digestive organs (stomach, pancreas, colon, and rectum). Those results provide evidence that inactivation of the APC gene p
High resolution genetic map of the adenomatous polyposis coli gene (APC) region
✍ Scribed by Olschwang, Sylviane ;Laurent-Puig, Pierre ;Melot, Thomas ;Thuille, Bénédicte ;Thomas, Gilles
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 833 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0148-7299
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Germline mutations of the putative tumor suppressor gene APC are associated in high frequency with the familial adenomatous polyposis, predisposing the patients to colorectal neoplasia. Similarly, sequence analyses have revealed that in more than half of patients with sporadic colorectal carcinoma o
## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm
## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with
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