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The absolute configurations of the metabolites of naphthalene and phenanthrene in mammalian systems.

✍ Scribed by Retsu Miura; Shigeru Honmaru; Masao Nakazaki

Book ID
104223028
Publisher
Elsevier Science
Year
1968
Tongue
French
Weight
190 KB
Volume
9
Category
Article
ISSN
0040-4039

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✦ Synopsis

Among various metabolle pathways 1) opened to oondeneed aromatic hydrocarbons, the one to yield optloally aatlve vlcinal dlhydxvdlhydroxy derivatives goes 8tereo8electlrely, and the role of oxygenaae 2) in thle prooesa has been studied Intensively.

(-)-9110-Dlhydra-9,10-dlhydroqphenanthrene (Ia) was isolated from the urines of rat8 or rabblts3) dosed with phenanthrene by lntraperltoneal InJectlon. The fate of naphthalene in their bodies 8hored very lnterestlng epeale8 8pOolflolty, e.g., (+)-1,2-dlhydro-1.2.dlhydroxynaphthalene (III) was found ln rabbit urine and its enantlomerlo modlflaatlon was isolated from rat urine 4),5) .

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