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The −491 A/T polymorphism in the regulatory region of the Apolipoprotein E gene and early-onset Alzheimer's disease

✍ Scribed by Gerwin Roks; Marc Cruts; Maria J Bullido; Hubert Backhovens; Maria J Artiga; Albert Hofman; Fernando Valdivieso; Christine Van Broeckhoven; Cornelia M Van Duijn


Book ID
117477236
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
50 KB
Volume
258
Category
Article
ISSN
0304-3940

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## Abstract The apolipoprotein E (APOE) gene is involved in lipid transport. A common polymorphism in this gene with the APOE\*2, APOE\*3, and APOE\*4 alleles influences plasma levels of apolipoprotein E and cholesterol. Besides its role in lipid transport, the APOE\*4 allele is a genetic risk fact