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The −491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism

✍ Scribed by Terrence Town; Daniel Paris; Danielle Fallin; Ranjan Duara; William Barker; Michael Gold; Fiona Crawford; Michael Mullan


Book ID
117476955
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
51 KB
Volume
252
Category
Article
ISSN
0304-3940

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Effect of the APOE-491A/T promoter polym
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## Abstract The apolipoprotein E (APOE) gene is involved in lipid transport. A common polymorphism in this gene with the APOE\*2, APOE\*3, and APOE\*4 alleles influences plasma levels of apolipoprotein E and cholesterol. Besides its role in lipid transport, the APOE\*4 allele is a genetic risk fact