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Apolipoprotein E promoter polymorphisms (−491A/T and −427T/C) and Alzheimer’s disease: no evidence of association in the Irish population

✍ Scribed by C. A. Lynch; J. Brazil; B. Cullen; D. Coakley; M. Gill; B. A. Lawlor; Z. Hawi

Book ID: 107526009
Publisher: Springer-Verlag
Year: 2007
Tongue: English
Weight: 166 KB
Volume: 177
Category: Article
ISSN: 1863-4362
DOI: 10.1007/s11845-007-0098-7

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## Abstract The apolipoprotein E (APOE) gene is involved in lipid transport. A common polymorphism in this gene with the APOE\*2, APOE\*3, and APOE\*4 alleles influences plasma levels of apolipoprotein E and cholesterol. Besides its role in lipid transport, the APOE\*4 allele is a genetic risk fact