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The 2,4-dinitrophenyl group for protection of hydroxyl function of tyrosine during solid-phase peptide synthesis

✍ Scribed by PHILOSOF-OPPENHEIMER, RACHEL ;PECHT, ISRAEL ;FRIDKIN, MATI


Book ID
115099747
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
498 KB
Volume
45
Category
Article
ISSN
0367-8377

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A method has been developed for the synthes/s ~'lhnb protected atuino acid residues via reductive alkylation of 2-hydroxy-4-melhoxybenzaldehyde with resin bound amino acids/peptides. The methodology potentially allows incorporation of limb protected atuino acids at any point in the synthesis of diff