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The 2,4-dimethylpent-3-yloxycarbonyl (Doc) group as a new, nucleophile-resistant protecting group for tyrosine in solid phase peptide synthesis

✍ Scribed by Katri Rosenthal; Amelie Karlström; Anders Undén


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
203 KB
Volume
38
Category
Article
ISSN
0040-4039

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A new hydroxy-protecting group for Ser, cyclohexyl, has been developed, and its application to the solid-phase peptide synthesis has been demonstrated successfully in combination with N°t-Boc protection and the Merrifield resin support.