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Thalidomide as a Nitric Oxide Synthase Inhibitor and Its Structural Development.

✍ Scribed by Rumiko Shimazawa; Hiroko Sano; Aya Tanatani; Hiroyuki Miyachi; Yuichi Hashimoto


Publisher
John Wiley and Sons
Year
2004
Weight
74 KB
Volume
35
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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ChemInform Abstract: 2-Iminopyrrolidines
✍ T. J. HAGEN; ET AL. ET AL. πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 29 KB πŸ‘ 2 views

A series of substituted 2iminopyrrolidines is prepared and evaluated as selective inhibitors of the human inducible isoform of nitric oxide synthase (NOS). The most potent analogue is (VI). The compound (+)-(VIII) is also a good inhibitor of human inducible NOS and potent in vivo in mouse models of