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TGFβ and BMP-2 Activation of the OPN Promoter: Roles of Smad- and Hox-Binding Elements

✍ Scribed by Thomas G. Hullinger; Quintin Pan; Hema L. Viswanathan; Martha J. Somerman

Book ID
115603868
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
88 KB
Volume
262
Category
Article
ISSN
0014-4827

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Transcription of the alpha2(I) collagen gene (COL1A2) in fibroblasts is potently induced by transforming growth factor-beta (TGF-beta). Smad family proteins function as intracellular signal transducers for TGF-beta that convey information from the cell membrane to the nucleus. In the present study,