The role of Pin1 in liver fibrosis: Regulation of Tgf-β1 expression and Smad2/3 phosphorylation
✍ Scribed by Yang, Jin Won; Wook, Keon
- Book ID
- 127143672
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 67 KB
- Volume
- 229
- Category
- Article
- ISSN
- 0378-4274
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## Abstract Transforming growth factor‐beta (TGF‐β) is an important growth inhibitor of epithelial cells, and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to tumorigenesis. Smad2 and Smad3 are direct mediators of TGF‐β signaling, however little is kno
## Abstract Transforming growth factor‐beta 1 (TGF‐β1) is an important growth inhibitor of epithelial cells and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to tumorigenesis. TGF‐β1 signals through the TGF‐β type I and type II receptors, and activates