✦ LIBER ✦

Genomic organization of the rat Smad7 gene: Identification and functional characterization of the Smad binding element responsible for negative feedback regulation of TGFβ signaling

✍ Scribed by S. Dooley; M. Stopa; D. Anhuf; L. Terstegen; P. Gatsios; A.M. Gressner

Book ID: 119526230
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 139 KB
Volume: 32
Category: Article
ISSN: 0168-8278
DOI: 10.1016/s0168-8278(00)80896-x

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Evidence for TGF-ß1 and bleomycin intrac

Evidence for TGF-ß1 and bleomycin intracellular signaling through autocrine regulation of Smad 3 binding to the proximal promoter of the Smad 7 gene

✍ Kenneth R. Cutroneo 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 218 KB

## Abstract Both Bleomycin and TGF‐β1 increase the transcription of the __COL1A1__ gene. Bleomycin acts through TGF‐β1. Bleomycin stimulates the COL1A1 promoter through the distal TGF‐β response element by intracellular and extracellular signaling. As demonstrated in this manuscript, Bleomycin's in