TGF-β: Regulation of extracellular matrix
✍ Scribed by Roberts, Anita B; McCune, Bryan K; Sporn, Michael B
- Book ID
- 109882306
- Publisher
- Nature Publishing Group
- Year
- 1992
- Tongue
- English
- Weight
- 326 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0085-2538
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Growth plate chondrocytes make TGF-1 in latent form (LTGF-1) and store it in the extracellular matrix via LTGF-1 binding protein (LTBP1). 1,25-(OH) 2 D 3 (1,25) regulates matrix protein production in growth zone (GC) chondrocyte cultures, whereas 24,25-(OH) 2 D 3 (24,25) does so in resting zone (
## Abstract ## Background and Objectives Keloids have been treated with flashlamp pulsed dye lasers (PDLs) with good results. We investigated whether PDL treatments induced keloid regression by decreasing growth factor‐β~1~ (TGF‐β~1~) induction, thereby reducing fibroblast proliferation and collag