Growth plate chondrocytes make TGF-1 in latent form (LTGF-1) and store it in the extracellular matrix via LTGF-1 binding protein (LTBP1). 1,25-(OH) 2 D 3 (1,25) regulates matrix protein production in growth zone (GC) chondrocyte cultures, whereas 24,25-(OH) 2 D 3 (24,25) does so in resting zone (
✦ LIBER ✦
Lysophospholipid regulates release and activation of latent TGF-β1 from chondrocyte extracellular matrix
✍ Scribed by I. Gay; Z. Schwartz; V.L. Sylvia; B.D. Boyan
- Book ID
- 116272819
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 571 KB
- Volume
- 1684
- Category
- Article
- ISSN
- 1388-1981
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## Abstract ## Background and Objectives Keloids have been treated with flashlamp pulsed dye lasers (PDLs) with good results. We investigated whether PDL treatments induced keloid regression by decreasing growth factor‐β~1~ (TGF‐β~1~) induction, thereby reducing fibroblast proliferation and collag