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Activation of Latent Transforming Growth Factor β1 by Stromelysin 1 in Extracts of Growth Plate Chondrocyte-Derived Matrix Vesicles

✍ Scribed by Shingo Maeda; David D. Dean; Isabel Gay; Zvi Schwartz; Barbara D. Boyan


Book ID
111486989
Publisher
American Society for Bone and Mineral Research
Year
2001
Tongue
English
Weight
197 KB
Volume
16
Category
Article
ISSN
0884-0431

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Transforming growth factor-beta1 (TGF-beta) is secreted in a latent form consisting of mature TGF-beta noncovalently associated with its amino-terminal propeptide, which is called latency associated peptide (LAP). Biological activity depends upon the release of TGF-beta from the latent complex follo