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TGF-β-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing

✍ Scribed by Schiller, Meinhard; Javelaud, Delphine; Mauviel, Alain


Book ID
117991343
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
318 KB
Volume
35
Category
Article
ISSN
0923-1811

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TGFbeta inducible early gene (TIEG) is a novel Krüppel-like transcriptional repressor that was recently shown to increase the activity of the TGFbeta/Smad signal transduction pathway by relieving negative feedback through repression of the inhibitory Smad7. Interestingly, while Smad7 is required for