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TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

✍ Scribed by Alliston, Tamara (author);Choy, Lisa (author);Ducy, Patricia (author);Karsenty, Gérard (author);Derynck, Rik (author)

Book ID
111748531
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
667 KB
Volume
20
Category
Article
ISSN
0261-4189

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## Abstract Transforming growth factor‐β (TGF‐β) is a multifunctional growth factor, affecting cell proliferation, apoptosis, and extracellular matrix homeostasis. It also plays critical roles in mammary gland development, one of which involves inhibition of the expression of milk proteins, such as