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TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

✍ Scribed by Alliston, T.


Book ID
111748530
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
667 KB
Volume
20
Category
Article
ISSN
0261-4189

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Core binding factor alpha 1 (Cbfa1) is an osteoblast-specific transcription factor essential to develop a mature osteoblast phenotype. However, its exact role in the signaling of various osteotropic-differentiating agents is still unclear. In this study, we assessed the effects of 1,25-(OH)(2)-D3 (D