Tetrafibricin: Synthesis of the C1−C13, C15−C25, and C27−C40 Fragments
✍ Scribed by BouzBouz, Samir; Cossy, Janine
- Book ID
- 125495728
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 94 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1523-7060
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📜 SIMILAR VOLUMES
Efficient syntheses of suitably functionalized top and bottom fragments of tetrafibricin are described. The bottom fragment is prepared by two consecutive Kocienski-Julia couplings, while the top fragment synthesis features a dithiane alkylation and a Horner-Wadsworth-Emmons reaction.
The stereocontrolled synthesis of a C15 C24 fragment of dolabelides is reported. The C19 and C21 hydroxyl-bearing stereocenters were installed using ruthenium-mediated asymmetric hydrogenations of cyclic hemiketal 4 and b-keto ester 7. The C25 C30 portion of dolabelides was prepared as well by ring