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Synthesis of C1–C20 and C21–C40 fragments of tetrafibricin

✍ Scribed by Venugopal Gudipati; Dennis P. Curran


Book ID
104098867
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
594 KB
Volume
52
Category
Article
ISSN
0040-4039

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✦ Synopsis


Efficient syntheses of suitably functionalized top and bottom fragments of tetrafibricin are described. The bottom fragment is prepared by two consecutive Kocienski-Julia couplings, while the top fragment synthesis features a dithiane alkylation and a Horner-Wadsworth-Emmons reaction.


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