Synthesis of C1–C20 and C21–C40 fragment
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Venugopal Gudipati; Dennis P. Curran
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Article
📅
2011
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Elsevier Science
🌐
French
⚖ 594 KB
Efficient syntheses of suitably functionalized top and bottom fragments of tetrafibricin are described. The bottom fragment is prepared by two consecutive Kocienski-Julia couplings, while the top fragment synthesis features a dithiane alkylation and a Horner-Wadsworth-Emmons reaction.