Solid-phase synthesis of N,Nโฒ substitute
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Dharmpal S. Dodd; Owen B. Wallace
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Article
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1998
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Elsevier Science
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French
โ 201 KB
An efficient method for the solid-phase synthesis of substituted guanidines is presented. A variety of alcohols react with resin-bound N,N'-bis(t-butoxycarbonyl)thiopseudourea under Mitsunobu conditions to give the corresponding alkylated thiopseudoureas. The guanidines are liberated from the resin