Solid-Phase Synthesis of N-Substituted Pyrrolidinone-Tethered N-Substituted Piperidines via Ugi Reaction
β Scribed by Liu, Zhang; Nefzi, Adel
- Book ID
- 117992060
- Publisher
- American Chemical Society
- Year
- 2010
- Tongue
- English
- Weight
- 351 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1520-4766
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π SIMILAR VOLUMES
An efficient method for the solid-phase synthesis of substituted guanidines is presented. A variety of alcohols react with resin-bound N,N'-bis(t-butoxycarbonyl)thiopseudourea under Mitsunobu conditions to give the corresponding alkylated thiopseudoureas. The guanidines are liberated from the resin
A series of N-substituted 3,5-bis(substituted-idene)piperidin-4-ones have been prepared using solidphase organic synthesis. The synthesis starts with a Michael addition with piperidin-4-one serving as the donor and REM resin as the acceptor. Various aldehydes were then utilized through a Knoevenagel