Tests of the biological activity of nor-vitamin B6
β Scribed by G. Pol; H. J. Klein Obbink
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 187 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0165-0513
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β¦ Synopsis
Abstract
Norβvitamin B~6~ is inactive as a substitute for vitamin B~6~ in growth tests with Saccharomyces carlsbergensis and does not inhibit the effect of vitamin B~6~. It has little, if any, effect on the growth of vitamin B~6~βdeficient rats.
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Methods have been developed for the simultaneous quantitative analysis of vitamin B6 forms in biological samples by isotope dilution mass spectrometry using deuterated forms of pyridoxine, pyridoxal, pyridoxamine, and pyridoxic acid. The biological fluid or tissue sample was homogenized and then tre
Three new derivatives of vitamin B, ?. 0"-succinyl-, 05'-s~~cinyl-, and 02'. 0"-disuccinyl-vitamin B, 1. whose a-ribose moieties of the nucleotide ligand are succinylated, were prepared by reaction of the vitamin with succinic anhydride. The first succinylstion took place rapidly and almost predomin