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Investigations in the vitamin B6-series: I. synthesis of nor-vitamin B6

✍ Scribed by B. van der Wal; Th. J. de Boer; H. O. Huisman

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
652 KB
Volume
80
Category
Article
ISSN
0165-0513

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Investigations in the vitamin B6−series:
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## Abstract Attempts are described to simplify the synthesis of vitamin B~6~ by a simultaneous reduction of the ester groups and reductive elimination of the chlorine atom in dimethyl 3‐amino‐6‐chloro‐2‐methylpyridine‐4,5‐dicarboxylate (III) with lithium aluminium hydride. After prolonged refluxing

Investigations in the vitamin B6-series:
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## Abstract The synthesis of 4,5‐dihydroxymethyl‐6‐hydroxy‐2‐methylpyridine, an isomer of vitamin B~6~, is described. This isomer is biologically inactive on the growth of __Saccharomyces carlsbergensis__.

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## Abstract 3‐Hydroxy‐4‐(hydroxymethyl)‐5‐(hydroxymethyl‐d~2~)‐2‐methylpyridine(pyridoxine‐d~2~) was prepared by reduction of α^4^‐3‐0‐isopropylidene‐5‐pyridoxic acid with lithium aluminum deuteride. Deuterium was inserted in the 2‐methyl group using base catalyzed exchange between deuterium oxide

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## Abstract The known synthesis of “Ichiba acid”, 2‐methyl‐3‐hydroxypyridine 4,5‐dicarboxylic acid (VII), starting from ethyl acetylpyruvate and cyanoacetamide, has been reinvestigated and simplified to a five step process. Several derivatives of Ichiba acid have been prepared including the triben