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Investigations in the vitamin B6−series: III. Reductions of an intermediate of the vitamin b6 synthesis with lithium aluminium hydride

✍ Scribed by B. van der Wal; Th. J. de Boer; H. O. Huisman

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 215 KB
Volume: 80
Category: Article
ISSN: 0165-0513
DOI: 10.1002/recl.19610800212

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✦ Synopsis

Abstract

Attempts are described to simplify the synthesis of vitamin B~6~ by a simultaneous reduction of the ester groups and reductive elimination of the chlorine atom in dimethyl 3‐amino‐6‐chloro‐2‐methylpyridine‐4,5‐dicarboxylate (III) with lithium aluminium hydride. After prolonged refluxing with a large excess of the reagent the chlorine free compound 3‐amino‐4,5‐dihydroxymethyl‐2‐methylpyridine (IV) could be isolated in low yield.

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## Abstract The synthesis of 4,5‐dihydroxymethyl‐6‐hydroxy‐2‐methylpyridine, an isomer of vitamin B~6~, is described. This isomer is biologically inactive on the growth of __Saccharomyces carlsbergensis__.