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Testican-1, an inhibitor of pro-MMP-2 activation, is expressed in cartilage

✍ Scribed by Heinz-J. Hausser; Ralf Decking; Rolf E. Brenner


Book ID
113732198
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
597 KB
Volume
12
Category
Article
ISSN
1063-4584

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Enhanced expression of the type IV collagenases MMP-2 and MMP-9, or lack of their inhibitors TIMP-1 and TIMP-2, has been associated with tumour invasion and metastatic potential in several experimental models. Regulation of enzyme activity is clearly a key step in tumour invasion, and recently a pot