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MMP-2 activation by membrane-type-1-MMP (MT1-MMP) in melanoma cells is dependent on TIMP-2 expression

✍ Scribed by Kurschat, P.; Röckel, D.; Faust, A.; Zigrino, P.; Nischt, R.; Klein, E.C.; Mauch, C.

Book ID
119562512
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
190 KB
Volume
16
Category
Article
ISSN
0923-1811

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## Abstract Membrane‐type metalloproteinase‐1 (MT1‐MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of pro‐MMP‐2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMP‐2 activation that yields to t