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Differential Roles of TIMP-4 and TIMP-2 in Pro-MMP-2 Activation by MT1-MMP

✍ Scribed by Sonia Hernandez-Barrantes; Yoichiro Shimura; Paul D. Soloway; QingXiang Amy Sang; Rafael Fridman

Book ID
115587410
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
87 KB
Volume
281
Category
Article
ISSN
0006-291X

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## Abstract Matrix metalloproteinases (MMPs) are zinc‐dependent proteases capable of degrading extracellular matrix components. The activity of these proteases is tightly regulated through the actions of the tissue inhibitors of metalloproteinases (TIMPs). Although the regulation of MMPs and TIMPs