✦ LIBER ✦

Regulation of TIMP-2, MT1-MMP, and MMP-2 expression during C2C12 differentiation

✍ Scribed by Gentian Lluri; Diane M. Jaworski

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 757 KB
Volume: 32
Category: Article
ISSN: 0148-639X
DOI: 10.1002/mus.20383

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Matrix metalloproteinases (MMPs) are zinc‐dependent proteases capable of degrading extracellular matrix components. The activity of these proteases is tightly regulated through the actions of the tissue inhibitors of metalloproteinases (TIMPs). Although the regulation of MMPs and TIMPs during physiological and pathological remodeling has been investigated in a number of systems, almost nothing is known about their role in skeletal muscle differentiation. To investigate the role of MMP‐mediated proteolysis during myogenesis, the regulation of TIMP‐2, MT1‐MMP, and MMP‐2 expression was investigated during differentiation of the mouse myoblastic C2C12 cell line. We show that this trio is upregulated coincident with myogenesis. The more diffuse spatial distribution of TIMP‐2 relative to MT1‐MMP and MMP‐2 suggests that TIMP‐2 may exert MMP‐independent functions during myogenesis. Elucidating the regulation of these molecules during muscle differentiation in vitro may lead to a better understanding of their role in pathological processes in muscle tissue in vivo. Muscle Nerve, 2005

📜 SIMILAR VOLUMES

Analysis of MT1-MMP and MMP2 expression

Analysis of MT1-MMP and MMP2 expression in human gastric cancers

✍ Masaki Mori; Koshi Mimori; Takeshi Shiraishi; Tatsuo Fujie; Kinya Baba; Hiroki K 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 217 KB 👁 2 views

## Membrane -type 1 matrix metalloproteinase (MT1-MMP) is a presumed activator of MMP2, which is one of the major proteinases in tumor cell invasion. In this study, we determined the clinico-pathologic significance of MT1-MMP expression in 68 human gastric carcinomas. The tumor-normal ratio (T/N r

Mechanical forces-induced human osteobla

Mechanical forces-induced human osteoblasts differentiation involves MMP-2/MMP-13/MT1-MMP proteolytic cascade

✍ Stéphane Barthelemi; Julien Robinet; Roselyne Garnotel; Frank Antonicelli; Estel 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 616 KB

## Abstract Matrix metalloproteinase (MMP) family proteins play diverse roles in many aspects of cellular processes such as osteoblastic differentiation. Besides, mechanical forces that occur in 3D collagen gel promote the osteoblastic phenotype and accelerate matrix mineralization. Although MMPs h

Expression of MMP-2 and MMP-9, their inh

Expression of MMP-2 and MMP-9, their inhibitors, and the activator MT1-MMP in primary breast carcinomas

✍ Jones, J. Louise; Glynn, P.; Walker, Rosemary A. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 321 KB 👁 2 views

Enhanced expression of the type IV collagenases MMP-2 and MMP-9, or lack of their inhibitors TIMP-1 and TIMP-2, has been associated with tumour invasion and metastatic potential in several experimental models. Regulation of enzyme activity is clearly a key step in tumour invasion, and recently a pot

Angiogenesis in vestibular schwannomas:

Angiogenesis in vestibular schwannomas: Expression of extracellular matrix factors MMP-2, MMP-9, and TIMP-1

✍ Martin Nue Møller; Kim Werther; Amarnadh Nalla; Sven-Eric Stangerup; Jens Thomse 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 618 KB

## Abstract ## Objectives/Hypothesis: Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are potent mediators of tumor angiogenesis. It has been demonstrated that vestibular schwannoma VEGF expression correlates with tumor growth pattern, whereas knowledge on the expres

Effects of radiation on the levels of MM

Effects of radiation on the levels of MMP-2, MMP-9 and TIMP-1 during morphogenic glial-endothelial cell interactions

✍ Chandrasekar Nirmala; Sushma L. Jasti; Raymond Sawaya; Anthanassios P. Kyritsis; 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 192 KB

Vascular endothelial growth factor expre

Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas

✍ Carine Munaut; Agnès Noël; Olivier Hougrand; Jean-Michel Foidart; Jacques Bonive 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 340 KB 👁 1 views

Vascular endothelial growth factor (VEGF) is the major endothelial mitogen in central nervous system neoplasms and it is expressed in 64-95% of glioblastomas (GBMs). Tumour cells are the main source of VEGF in GBMs whereas VEGF receptors (VEGFR-1, its soluble form sVEGFR-1, VEGFR-2 and neuropilin-1)