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Expression of Matrix Metalloprotease-2 (MMP-2) and the Activator Membrane Type 1 (MT1-MMP) in Canine Mammary Carcinomas

✍ Scribed by S. Papparella; B. Restucci; O. Paciello; P. Maiolino


Book ID
114475790
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
212 KB
Volume
126
Category
Article
ISSN
0021-9975

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Enhanced expression of the type IV collagenases MMP-2 and MMP-9, or lack of their inhibitors TIMP-1 and TIMP-2, has been associated with tumour invasion and metastatic potential in several experimental models. Regulation of enzyme activity is clearly a key step in tumour invasion, and recently a pot